Amongst the many gems in the interview, I particularly liked:
On The Wire, we were trying to explore this stuff you don't see—the dope on the table, all that has been done to death. Sometimes the real poetry of police work is a couple of detectives with their feet on a desk in the backroom looking at ballistics. And that sounds like anti-drama. But that's the trick to making good drama; the drama has to be earned. There have to be moments of anti-drama. You can't make a good show based on pure verisimilitude, pure anti-drama. But you have to acknowledge a lot of ordinary life. Most TV doesn't do that.
If I had to write a police procedural right now, I'd put a gun to my head. And I really have to say this, even Homicide [on which Simon was a producer and writer] was prisoner of the form. On shows where the arrest matters, where it's about good and evil, punishing crime, the poor and the rich, the suspect exists to exalt the good guys, to make the Sipowiczs and the Pembletons and the Joe Fridays that much more moral, that much more righteous, that much more intellectualized. It's to validate their point of view and the point of view of society. So, you end up with same stilted picture of the underclass. Either they're the salt of earth looking for a break, and not at all responsible, or they're venal and evil and need to be punished. That's a good precedent for creating an alienated America.
And this contextualises the show really nicely:
In our heads we're writing a Greek tragedy, but instead of the gods being petulant and jealous Olympians hurling lightning bolts down at our protagonists, it's the Postmodern institutions that are the gods. And they are gods. And no one is bigger.
If you haven’t been watching this magnificent drama what the hell are you waiting for? Actually, I don’t want to hear your excuses. Go and get the DVDs now.